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Recombinant beta 2 Adrenergic Receptor antibody

This anti-beta 2 Adrenergic Receptor antibody is a Rabbit Chimeric antibody detecting beta 2 Adrenergic Receptor in WB, ELISA, IF and IP. Suitable for Human.
Catalog No. ABIN7072671

Quick Overview for Recombinant beta 2 Adrenergic Receptor antibody (ABIN7072671)

Target

See all beta 2 Adrenergic Receptor (ADRB2) Antibodies
beta 2 Adrenergic Receptor (ADRB2) (Adrenergic, beta-2-, Receptor, Surface (ADRB2))

Antibody Type

Recombinant Antibody

Reactivity

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Human

Host

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Rabbit

Clonality

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Chimeric

Conjugate

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This beta 2 Adrenergic Receptor antibody is un-conjugated

Application

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Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Clone

13D6
  • Purpose

    Anti-Beta 2 adrenergic receptor [13D6], Rabbit IgG, kappa

    Specificity

    13D6 antibody recognizes human beta-2 adrenergic receptor. It was reported that this antibody recognizes extracellualr domains of the receptor (Han et al., 2012). Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds adrenaline with far grater affinity than noradrenaline.

    Characteristics

    Original Species of Ab: Mouse

    Original Format of Ab: IgG1

    Purification

    Protein A affinity purified

    Immunogen

    This antibody was raised by immunizing mice with beta-2 adrenergic receptor.

    Isotype

    IgG kappa
  • Application Notes

    This antibody is recommended for the identification and analysis of the β2-adrenergic receptor. For instance, tt was used to immunostain vascular smooth muscle cells (VSMCs) against beta-2-adrenergic receptor to determine the fate of beta-2ARs ubiquitinated in a carvedilol responsive manner (Han et al., 2012). Furthermore, the antibody was utilized in the quantification of the surface level of β-2ARs via ELISA (Han et al., 2012).

    Comment

    This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

    Restrictions

    For Research Use only
  • Concentration

    1 mg/mL

    Buffer

    PBS with 0.02 % Proclin 300.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C,-20 °C

    Storage Comment

    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Target

    beta 2 Adrenergic Receptor (ADRB2) (Adrenergic, beta-2-, Receptor, Surface (ADRB2))

    Alternative Name

    Beta 2 adrenergic receptor

    Background

    R11E1, Beta-2 adrenergic receptor, Beta-2 adrenoreceptor, Beta-2 adrenoceptor, β-2 adrenergic receptor, β-2 adrenoreceptor, β-2 adrenoceptor, β2AR, β2-AR, I3D6

    UniProt

    P07550

    Pathways

    cAMP Metabolic Process, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Brown Fat Cell Differentiation
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