FOSB antibody

Catalog No. ABIN7073925

The Rabbit Polyclonal anti-FOSB antibody is suitable to detect FOSB in samples from Human, Mouse and Rat. It has been validated for WB.

Quick Overview for FOSB antibody (ABIN7073925)

Target: FOSB (FBJ Murine Osteosarcoma Viral Oncogene Homolog B (FOSB))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOSB antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FOSB Antibody

Cross-Reactivity: Human, Rat

Purification: Affinity purification

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse FOSB

Application Details

Application Notes: WB (H,M,R) 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for FOSB

Target: FOSB (FBJ Murine Osteosarcoma Viral Oncogene Homolog B (FOSB))

Alternative Name: Fos B

Background: The FOS gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipperproteins that can dimerize with proteins of the JUN family (e.g., c-Jun, JunD), thereby forming thetranscription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. FosB and its truncated splice variants, ΔFosB and further truncated Δ2ΔFosB, are all involved in osteosclerosis, although Δ2ΔFosB lacks a knowntransactivation domain, in turn preventing it from affecting transcription through the AP-1 complex.

Molecular Weight: 36 kDa

Gene ID: 14282

NCBI Accession: NP_032062

UniProt: P13346