MPL antibody

Catalog No. ABIN7074718

The Rabbit Polyclonal anti-MPL antibody (ABIN7074718) specifically detects MPL in IHC and IF. The antibody is reactive with Mouse and Rat samples.

Quick Overview for MPL antibody (ABIN7074718)

Target: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MPL antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-MPL Antibody

Cross-Reactivity: Rat

Purification: Affinity purification

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse TPOR

Application Details

Application Notes: IHC/IF (M,R) 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for MPL

Target: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Alternative Name: TPOR/MPL

Background: The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

Gene ID: 17480

NCBI Accession: NP_001116421

UniProt: Q08351

Pathways: JAK-STAT Signaling