This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Target
TOR1A
(Torsin Family 1, Member A (Torsin A) (TOR1A))
Alternative Name
Torsin A/DYT1
Background
TOR1A (torsin A), also known as DYT1, is a member of the AAA family of adenosine triphosphatases (ATPases) that mediate chaperone and other functions involved in conformational modeling of proteins, protection from stress, and targeting of proteins to cellular organelles. TOR1A primarily localizes to the ER while exposure to oxidative stress causes the redistribution to cell surface protrusions. Mutations in gene encoding TOR1A cause the most severe form of hereditary dystonia, termed early onset, generalized dystonia.