ZNF746 antibody

Catalog No. ABIN7076272

Product Details anti-ZNF746 Antibody

Target: ZNF746 (Zinc Finger Protein 746 (ZNF746))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZNF746 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Rat

Purification: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse PARIS

Application Details

Application Notes: WB (H) 1:500-1:1000, IHC/IF (M,R) 1:1500-1:3000/1:1500-1:3000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for ZNF746

Target: ZNF746 (Zinc Finger Protein 746 (ZNF746))

Alternative Name: PARIS (ZNF746 Products)

Synonyms: PARIS antibody, 2810407L07Rik antibody, AI317225 antibody, Znf746 antibody, RGD1306209 antibody, zinc finger protein 746 antibody, ZNF746 antibody, Zfp746 antibody

Background: ZNF746, also named as PARIS, which belongs to the krueppel C2H2-type zinc-finger protein family. ZNF746 mainly localizes to the cytoplasm and probably translocates to the nucleus to repress selected genes. ZNF746 as a transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. ZNF746 may act as a downstream effector of PRKN and contribute to neurodegeneration in Parkinson disease cases caused by defects in PRKN.

Molecular Weight: 100 kDa

Gene ID: 69228

NCBI Accession: NP_001156947

UniProt: Q3U133