Quick Overview for Lambda-IgLC antibody (FITC) (ABIN7076305)
Target
Lambda-IgLC
(lambda Light Chain (Lambda-IgLC))
Reactivity
Human
Host
Mouse
Clonality
Monoclonal
Conjugate
This Lambda-IgLC antibody is conjugated to FITC
Application
Flow Cytometry (FACS)
Grade
GMP Grade (Analyte)
Clone
HP6054
Purpose
Anti-Lambda Light Chain FITC Antibody
Characteristics
The clone HP6054 specifically binds with both soluble and membrane bound human lambda light chain of immunoglobulin but not binds with the kappa light chain or heavy chain. Lambda light chains are primarily expressed on the surface of B cells in lymphoid tissues. Each B cell expresses only one class of light chain kappa or lambda. In serum of a healthy individual, the total kappa to lambda ratio is approximately 3:1 while measuring as intact whole antibodies or 1:1.5 while measuring as free light chains. Various clinical research data claim that any highly divergent ratio of kappa to lambda indicative of neoplasm. HP6054 is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas.
Purification
Purified
Purity
>95 %
Immunogen
Purified human IgG myeloma proteins covalently coupled to polyaminostyrene (PAS) microbeads
Lambda-IgLC
Reactivity: Rat
WB, IHC (p), IF (cc), IF (p), ELISA, IHC (fro)
Host: Rabbit
Polyclonal
unconjugated
Application Notes
FC: 5 µL/test We recommend that every lab carries out an initial titration study before running your samples to ensure that the optimal concentration is selected for your application.