TSC1 antibody (AA 131-230) (Biotin)

Catalog No. ABIN704848

This Rabbit Polyclonal antibody specifically detects TSC1 in ELISA and WB. It exhibits reactivity toward Sheep.

Quick Overview for TSC1 antibody (AA 131-230) (Biotin) (ABIN704848)

Target: TSC1 (Tuberous Sclerosis 1 (TSC1))

Reactivity: Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSC1 antibody is conjugated to Biotin

Application: ELISA, Western Blotting (WB)

Product Details anti-TSC1 Antibody (Biotin)

Binding Specificity: AA 131-230

Cross-Reactivity: Sheep

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Hamartin

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for TSC1

Target: TSC1 (Tuberous Sclerosis 1 (TSC1))

Alternative Name: Hamartin/TSC1

Background:

Synonyms: LAM, TSC1, Tuberous sclerosis 1 protein, TSC1_HUMAN.

Background: Hamartin, or TSC1, is a suspected tumor suppressor implicated in the disease tuberous sclerosis 1. It is a negative regulator of cell division controlling the transition from G0/G1 to S phase, and it seems to act through the phosphatidylinositol 3 kinase/Akt pathway. TSC1 interacts with tuberin m(TSC2), which is thought to be a GAP (GTPase Activating Protein) for the Rap1 and Rab5 small G Proteins. The Hamartin/Tuberin complex has been shown to inhibit mTor. Hamartin has also been shown to interact with ERM (Ezrin-Radixin-Moesin) proteins and with F-actin, suggesting a role for TSC proteins in modulation of cell adhesion and morphology.

Gene ID: 7248

UniProt: Q92574

Pathways: RTK Signaling, AMPK Signaling, Regulation of Cell Size, Tube Formation