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Sphingomyelin Synthase 1 antibody (AA 331-413) (Biotin)

SGMS1 Reactivity: Mouse WB, ELISA, IHC (p), IHC (fro) Host: Rabbit Polyclonal Biotin
Catalog No. ABIN705373
  • Target See all Sphingomyelin Synthase 1 (SGMS1) Antibodies
    Sphingomyelin Synthase 1 (SGMS1)
    Binding Specificity
    • 14
    • 8
    • 8
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    AA 331-413
    Reactivity
    • 28
    • 20
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Mouse
    Host
    • 42
    Rabbit
    Clonality
    • 42
    Polyclonal
    Conjugate
    • 15
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Sphingomyelin Synthase 1 antibody is conjugated to Biotin
    Application
    • 38
    • 19
    • 15
    • 13
    • 13
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Mouse
    Predicted Reactivity
    Human,Rat,Dog,Cow,Horse,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Sphingomyelin Synthase 1
    Isotype
    IgG
    Top Product
    Discover our top product SGMS1 Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for 12 months.
    Expiry Date
    12 months
  • Target
    Sphingomyelin Synthase 1 (SGMS1)
    Alternative Name
    Sphingomyelin Synthase 1 (SGMS1 Products)
    Synonyms
    MGC81436 antibody, TMEM23 antibody, MOB antibody, MOB1 antibody, SMS1 antibody, hmob33 antibody, 9530058O11Rik antibody, AI841905 antibody, C80702 antibody, Mob antibody, Sms1 antibody, Sor1 antibody, Tmem23 antibody, sphingomyelin synthase 1 antibody, sphingomyelin synthase 1 S homeolog antibody, phosphatidylcholine:ceramide cholinephosphotransferase 1 antibody, SGMS1 antibody, sgms1.S antibody, LOC100013212 antibody, Sgms1 antibody
    Background

    Synonyms: MOB, MOB1, SMS1, TMEM23, hmob33, Phosphatidylcholine:ceramide cholinephosphotransferase 1, Medulla oblongata-derived protein, Protein Mob, Sphingomyelin synthase 1, Transmembrane protein 23, SGMS1

    Background: Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.

    Gene ID
    259230
    UniProt
    Q86VZ5
    Pathways
    Cellular Response to Molecule of Bacterial Origin
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