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ECT2 antibody (AA 201-450)

This anti-ECT2 antibody is a Mouse Monoclonal antibody detecting ECT2 in WB. Suitable for Human.
Catalog No. ABIN7091081

Quick Overview for ECT2 antibody (AA 201-450) (ABIN7091081)

Target

See all ECT2 Antibodies
ECT2 (Epithelial Cell Transforming Sequence 2 Oncogene (ECT2))

Reactivity

  • 63
  • 12
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  • 1
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Human

Host

  • 59
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Mouse

Clonality

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Monoclonal

Conjugate

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This ECT2 antibody is un-conjugated

Application

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Western Blotting (WB)

Clone

D12R1
  • Binding Specificity

    • 15
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    • 1
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    AA 201-450

    Predicted Reactivity

    Human

    Immunogen

    KLH conjugated synthetic peptide derived from human ECT2
  • Application Notes

    WB 1:300-5000

    Restrictions

    For Research Use only
  • Concentration

    0.5 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C,-20 °C

    Storage Comment

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Expiry Date

    12 months
  • Target

    ECT2 (Epithelial Cell Transforming Sequence 2 Oncogene (ECT2))

    Alternative Name

    ECT2

    Background

    Synonyms: ECT 2, ECT-2, ECT2 protein, Epithelial cell transforming sequence 2, Epithelial cell transforming sequence 2 oncogene, Epithelial cell transforming sequence 2 oncogene protein, FLJ10461, MGC138291, Protein ECT2, ECT2_HUMAN, Epithelial cell-transforming sequence 2 oncogene.

    Background: Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly, regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity, participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits Phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.

    Gene ID

    1894

    UniProt

    Q9H8V3

    Pathways

    Neurotrophin Signaling Pathway, Cell-Cell Junction Organization
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