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IKZF1 antibody

This Rabbit Monoclonal antibody specifically detects IKZF1 in WB, IF, IHC (p) and ICC. It exhibits reactivity toward Human.
Catalog No. ABIN7091238

Quick Overview for IKZF1 antibody (ABIN7091238)

Target

See all IKZF1 Antibodies
IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))

Reactivity

  • 57
  • 39
  • 17
  • 5
  • 5
  • 4
  • 4
  • 4
  • 4
  • 1
  • 1
  • 1
  • 1
Human

Host

  • 59
  • 12
  • 2
Rabbit

Clonality

  • 58
  • 15
Monoclonal

Conjugate

  • 40
  • 4
  • 4
  • 4
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This IKZF1 antibody is un-conjugated

Application

  • 57
  • 24
  • 20
  • 18
  • 13
  • 13
  • 8
  • 8
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  • 4
  • 3
  • 3
  • 2
  • 1
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  • 1
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Clone

IK3C9
  • Cross-Reactivity

    Human

    Purification

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human IKZF1

    Isotype

    IgG
  • Application Notes

    WB 1:300-5000
    IHC-P 1:200-400
    IF()
    ICC 1:100-500

    Restrictions

    For Research Use only
  • Concentration

    1 mg/mL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C,-20 °C

    Storage Comment

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Expiry Date

    12 months
  • Target

    IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))

    Alternative Name

    IKZF1

    Background

    Synonyms: IKAROS family zinc finger 1 (Ikaros), PRO0758, CLL associated antigen KW 6, DNA-binding protein Ikaros, hIk 1, hIk-1, IK1, Ikaros (zinc finger protein), IKAROS, Ikaros family zinc finger protein 1, IKZF1_HUMAN, LYF1, Lymphoid transcription factor LyF-1, zinc finger protein subfamily 1A 1, ZNFN1A1.

    Background: This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]

    Gene ID

    10320

    UniProt

    Q13422

    Pathways

    Production of Molecular Mediator of Immune Response
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