IKZF1 antibody
Quick Overview for IKZF1 antibody (ABIN7091238)
Target
See all IKZF1 AntibodiesReactivity
Host
Clonality
Conjugate
Application
Clone
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Cross-Reactivity
- Human
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Purification
- Purified by Protein A.
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Immunogen
- KLH conjugated synthetic peptide derived from human IKZF1
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Isotype
- IgG
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Application Notes
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WB 1:300-5000
IHC-P 1:200-400
IF()
ICC 1:100-500 -
Restrictions
- For Research Use only
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Concentration
- 1 mg/mL
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Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C,-20 °C
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Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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Expiry Date
- 12 months
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- IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))
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Alternative Name
- IKZF1
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Background
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Synonyms: IKAROS family zinc finger 1 (Ikaros), PRO0758, CLL associated antigen KW 6, DNA-binding protein Ikaros, hIk 1, hIk-1, IK1, Ikaros (zinc finger protein), IKAROS, Ikaros family zinc finger protein 1, IKZF1_HUMAN, LYF1, Lymphoid transcription factor LyF-1, zinc finger protein subfamily 1A 1, ZNFN1A1.
Background: This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]
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Gene ID
- 10320
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UniProt
- Q13422
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Pathways
- Production of Molecular Mediator of Immune Response
Target
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