Integrin beta 3 antibody (AA 251-350)
-
- Target See all Integrin beta 3 (ITGB3) Antibodies
- Integrin beta 3 (ITGB3)
-
Binding Specificity
- AA 251-350
-
Reactivity
- Human, Mouse
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This Integrin beta 3 antibody is un-conjugated
-
Application
- Western Blotting (WB), ELISA
- Cross-Reactivity
- Human, Mouse
- Predicted Reactivity
- Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Integrin beta 3
- Isotype
- IgG
- Top Product
- Discover our top product ITGB3 Primary Antibody
-
-
- Application Notes
-
WB 1:300-5000
ELISA 1:500-1000 - Restrictions
- For Research Use only
-
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
-
- Target
- Integrin beta 3 (ITGB3)
- Alternative Name
- Integrin beta 3 (ITGB3 Products)
- Synonyms
- BDPLT16 antibody, BDPLT2 antibody, CD61 antibody, GP3A antibody, GPIIIa antibody, GT antibody, INGRB3 antibody, integrin antibody, INTB3 antibody, GPIIIA antibody, cd61 antibody, gp3a antibody, itgb3 antibody, itgb3.2 antibody, itgb3.1 antibody, integrin subunit beta 3 antibody, integrin beta 3 antibody, integrin subunit beta 3 L homeolog antibody, integrin beta 3a antibody, integrin beta 3b antibody, ITGB3 antibody, Itgb3 antibody, itgb3.L antibody, itgb3a antibody, itgb3b antibody
- Background
-
Synonyms: Integrin beta-3, Integrin beta chain, ??3 precursor, Integrin Beta 3, CD 61, CD61, CD61 antigen, GP3A, GPIIIa, HPA 1, HPA 4, Integrin beta 3 (platelet glycoprotein IIIa antigen CD61), Integrin beta chain beta 3, ITG B3, ITGB 3, ITGB3, NAIT, Platelet fibrinogen receptor beta subunit, Platelet glycoprotein IIIa, platelet glycoprotein IIIa precursor, Platelet membrane glycoprotein IIIa, PTP, ITB3_HUMAN.
Background: Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
- Gene ID
- 3690
- UniProt
- P05106
- Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex
-