MAGED1 antibody (AA 50-200)

Catalog No. ABIN7091377

The Mouse Monoclonal anti-MAGED1 antibody has been validated for WB. It is suitable to detect MAGED1 in samples from Human.

Quick Overview for MAGED1 antibody (AA 50-200) (ABIN7091377)

Target: MAGED1 (Melanoma Antigen Family D, 1 (MAGED1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MAGED1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: C5D3

Product Details anti-MAGED1 Antibody

Binding Specificity: AA 50-200

Predicted Reactivity: Human

Immunogen: KLH conjugated synthetic peptide derived from human MAGED1

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for MAGED1

Target: MAGED1 (Melanoma Antigen Family D, 1 (MAGED1))

Alternative Name: MAGED1

Background:

Synonyms: DLXIN 1, MAGD1_HUMAN, MAGE D1 antigen, MAGE tumor antigen CCF, MAGE-D1 antigen, Melanoma antigen family D 1, Melanoma associated antigen D1, Melanoma-associated antigen D1, Neurotrophin receptor interacting MAGE homolog, Neurotrophin receptor-interacting MAGE homolog, NRAGE, PP2250.

Background: Involved in the apoptotic response after nerve growthfactor (NGF) binding in neuronal cells. Binds NGFR/p75NTR andantagonizes its association with NTRK1/TrkA, inhibits cell cycleprogression, and facilitates NGFR-mediated apoptosis. May act as aregulator of the function of DLX family members. May regulateTP53/p53 transcriptional activity and inhibit cell proliferation.Enhances TP53 phosphorylation and accumulation. May enhanceubiquitin ligase activity of RING-type zinc finger-containing E3ubiquitin-protein ligases. Proposed to act through recruitmentand/or stabilization of the Ubl-conjugating enzyme (E2) at theE3:substrate complex.

Gene ID: 9500

UniProt: Q9Y5V3

Pathways: Neurotrophin Signaling Pathway