MCMBP antibody (AA 551-642) (Biotin)

Catalog No. ABIN7091413

The Rabbit Polyclonal anti-MCMBP antibody is suitable to detect MCMBP in samples from Human. It has been validated for IHC (p) and IHC (fro).

Quick Overview for MCMBP antibody (AA 551-642) (Biotin) (ABIN7091413)

Target: MCMBP (Minichromosome Maintenance Complex Binding Protein (MCMBP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MCMBP antibody is conjugated to Biotin

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-MCMBP Antibody (Biotin)

Binding Specificity: AA 551-642

Purpose: MCM-BP Polyclonal Antibody, Biotin Conjugated

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MCM-BP

Isotype: IgG

Application Details

Application Notes: IHC-P(1:100-500), IHC-F(1:100-500)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for MCMBP

Target: MCMBP (Minichromosome Maintenance Complex Binding Protein (MCMBP))

Alternative Name: MCM-BP

Background:

Synonyms: C10orf119 , chromosome 10 open reading frame 119 , MCM-binding protein , MCM-BP , mcmbp , MCMBP_HUMAN , Mini-chromosome maintenance complex-binding protein , Minichromosome maintenance complex binding protein.

Background: Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP, probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion.

Gene ID: 79892

UniProt: Q9BTE3

Pathways: Chromatin Binding