PIN1 antibody

Catalog No. ABIN7091519

The Mouse Monoclonal anti-PIN1 antibody (Clone F12S3) (ABIN7091519) specifically detects PIN1 in WB. The antibody is reactive with Human samples.

Quick Overview for PIN1 antibody (ABIN7091519)

Target: PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PIN1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: F12S3

Product Details anti-PIN1 Antibody

Predicted Reactivity: Human,Mouse,Cow

Immunogen: Recombinant human UBL5 (Fragment) (His-tagged).

Isotype: IgG1

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for PIN1

Target: PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))

Alternative Name: PIN1

Background:

Synonyms: DOD, NIMA interacting 1, Peptidyl prolyl cis trans isomerase NIMA interacting 1, Peptidyl prolyl cis/trans isomerase NIMA interacting, Pin 1, PPIase Pin1, Prolyl isomerase, Protein (peptidylprolyl cis/trans isomerase) NIMA interacting 1, Protein NIMA interacting 1, Rotamase Pin1, UBL 5, UBL5, PIN1_HUMAN.

Background: Essential PPIase that regulates mitosis presumably byinteracting with NIMA and attenuating its mitosis-promotingactivity. Displays a preference for an acidic residue N-terminal tothe isomerized proline bond. Catalyzes pSer/Thr-Pro cis/transisomerizations. Down-regulates kinase activity of BTK. Cantransactivate multiple oncogenes and induce centrosomeamplification, chromosome instability and cell transformation.Required for the efficient dephosphorylation and recycling of RAF1after mitogen activation.

Gene ID: 5300

UniProt: Q13526