RIPK3 antibody

Catalog No. ABIN7091641

The Mouse Monoclonal anti-RIPK3 antibody has been validated for WB. It is suitable to detect RIPK3 in samples from Human.

Quick Overview for RIPK3 antibody (ABIN7091641)

Target: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RIPK3 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: D11F6

Product Details anti-RIPK3 Antibody

Predicted Reactivity: Human

Immunogen: Recombinant human RIPK3.

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for RIPK3

Target: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Alternative Name: RIPK3

Background:

Synonyms: Receptor interacting protein 3, Receptor interacting serine threonine kinase 3, Receptor interacting serine/threonine protein kinase 3, Receptor-interacting protein 3, Receptor-interacting serine/threonine-protein kinase 3, RIP 3, RIP like protein kinase 3, RIP-3, RIP-like protein kinase 3, RIPK 3, RIPK3_HUMAN.

Background: Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

Gene ID: 11035

UniProt: Q9Y572

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades