TSC1 antibody

Catalog No. ABIN7091774

The Mouse Monoclonal anti-TSC1 antibody (Clone K6F13) (ABIN7091774) specifically detects TSC1 in WB. The antibody is reactive with Human samples.

Quick Overview for TSC1 antibody (ABIN7091774)

Target: TSC1 (Tuberous Sclerosis 1 (TSC1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TSC1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: K6F13

Product Details anti-TSC1 Antibody

Predicted Reactivity: Human

Immunogen: Recombinant human TSC1 (Fragment) (His-tagged).

Isotype: IgG2b

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for TSC1

Target: TSC1 (Tuberous Sclerosis 1 (TSC1))

Alternative Name: TSC1

Background:

Synonyms: LAM, Hamartin, Tuberous sclerosis 1 protein, TSC1_HUMAN, KIAA0243, TSC, Tuberous sclerosis 1.

Background: In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.

Gene ID: 7248

UniProt: Q92574

Pathways: RTK Signaling, AMPK Signaling, Regulation of Cell Size, Tube Formation