TSC1 antibody (pThr416)

Catalog No. ABIN1881922

This Rabbit Polyclonal antibody specifically detects TSC1 in DB. It exhibits reactivity toward Mouse. It has been mentioned in 2+ publications

Quick Overview for TSC1 antibody (pThr416) (ABIN1881922)

Target: TSC1 (Tuberous Sclerosis 1 (TSC1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSC1 antibody is un-conjugated

Application: Dot Blot (DB)

Clone: RB42189

Product Details anti-TSC1 Antibody

Binding Specificity: pThr416

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This mouse TSC1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T416 of mouse TSC1.

Isotype: Ig Fraction

Application Details

Application Notes: DB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-TSC1 antibody (ABIN1881922)

Akpa, Oyejola: "Modeling the transmission dynamics of HIV/AIDS epidemics: an introduction and a review." in: Journal of infection in developing countries, Vol. 4, Issue 10, pp. 597-608, (2010) (PubMed).

Kladney, Cardiff, Kwiatkowski, Chiang, Weber, Arbeit, Lu: "Tuberous sclerosis complex 1: an epithelial tumor suppressor essential to prevent spontaneous prostate cancer in aged mice." in: Cancer research, Vol. 70, Issue 21, pp. 8937-47, (2010) (PubMed).

Target Details for TSC1

Target: TSC1 (Tuberous Sclerosis 1 (TSC1))

Alternative Name: TSC1

Background: In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).

Molecular Weight: 128746

NCBI Accession: NP_075025

UniProt: Q9EP53

Pathways: RTK Signaling, AMPK Signaling, Regulation of Cell Size, Tube Formation