ZEB1 antibody (AA 51-150)

Catalog No. ABIN7091835

Product Details anti-ZEB1 Antibody

Target: ZEB1 (Zinc Finger E-Box Binding Homeobox 1 (ZEB1))

Binding Specificity: AA 51-150

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ZEB1 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: Human

Immunogen: KLH conjugated synthetic peptide derived from human ZEB1

Clone: Z6F8

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for ZEB1

Target: ZEB1 (Zinc Finger E-Box Binding Homeobox 1 (ZEB1))

Alternative Name: ZEB1 (ZEB1 Products)

Background:

Synonyms: AREB 6, AREB6, BZP, Delta crystallin enhancer binding factor 1, DELTA EF1, FECD6, MGC133261, Negative regulator of IL 2, Negative regulator of IL2, NIL 2 A, NIL 2 A zinc finger protein, NIL 2A, NIL-2-A zinc finger protein, NIL2A, Posterior polymorphous corneal dystrophy 3, PPCD3, Represses interleukin 2 expression, TCF 8, TCF-8, TCF8, Transcription factor 8 (represses interleukin 2 expression), Transcription factor 8, ZEB 1, ZEB,ZEB1_HUMAN, ZFHEP, ZFHX 1A, ZFHX1A, Zinc finger E box binding homeobox 1, Zinc finger E-box-binding homeobox 1, Zinc finger homeodomain enhancer binding protein.

Background: Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.

Gene ID: 6935

UniProt: P37275

Pathways: Regulation of Muscle Cell Differentiation