CTLA4 antibody (AA 36-161) (Biotin)

Catalog No. ABIN7092999

This Rabbit Monoclonal antibody specifically detects CTLA4 in FACS and ELISA. It exhibits reactivity toward Human.

Quick Overview for CTLA4 antibody (AA 36-161) (Biotin) (ABIN7092999)

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CTLA4 antibody is conjugated to Biotin

Application: Flow Cytometry (FACS), ELISA

Clone: DM50

Product Details anti-CTLA4 Antibody (Biotin)

Binding Specificity: AA 36-161

Purification: Purified from cell culture supernatant by affinity chromatography

Immunogen: Recombinant human  CTLA4(Gln36-Ser161) (ABIN6961090) produced by using human HEK293 cells

Isotype: IgG

Application Details

Application Notes: ELISA 1/5000-10000,Flow Cyt  1/100

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute with deionized water

Buffer: 50 % Glycerol, PBS, pH 7.4, 0.1 % BSA,0.1 % Procline 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details for CTLA4

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Alternative Name: CTLA4

Background: Synonyms:CTLA4, CD152
Description:Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.

Molecular Weight: 24.6 kDa

Gene ID: 1493

UniProt: P16410

Pathways: Cancer Immune Checkpoints