Mesothelin antibody (AA 296-580) (Biotin)

Catalog No. ABIN7093016

The Biotin-conjugated Rabbit Monoclonal anti-Mesothelin antibody (Clone DM71) (ABIN7093016) specifically detects Mesothelin in ELISA and FACS. The antibody is reactive with Human samples.

Quick Overview for Mesothelin antibody (AA 296-580) (Biotin) (ABIN7093016)

Target: Mesothelin (MSLN)

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Mesothelin antibody is conjugated to Biotin

Application: ELISA, Flow Cytometry (FACS)

Clone: DM71

Product Details anti-Mesothelin Antibody (Biotin)

Binding Specificity: AA 296-580

Purpose: Biotinylated Anti-mesothelin antibody(DM71), Rabbit mAb

Purification: Purified from cell culture supernatant by affinity chromatography

Immunogen: Recombinant human mesothelin (Glu296-Gly580) (ABIN6961104) produced by using human HEK293 cells

Isotype: IgG

Application Details

Application Notes: ELISA 1:5000-10000, Flow Cyt 1:100

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please see Certificate of Analysis for specific instructions of reconstitution.

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details for Mesothelin

Target: Mesothelin (MSLN)

Alternative Name: MSLN

Background: Synonyms:MSLN, Mesothelin, MPF
Description:This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Molecular Weight: 68.9kDa

Gene ID: 10232

UniProt: Q13421

Pathways: EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process