OAS1 antibody

Catalog No. ABIN7111100

The Rabbit Polyclonal anti-OAS1 antibody has been validated for WB, IHC and ELISA. It is suitable to detect OAS1 in samples from Human, Mouse and Rat.

Quick Overview for OAS1 antibody (ABIN7111100)

Target: OAS1 (2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OAS1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-OAS1 Antibody

Purpose: OAS1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: 2',5'-oligoadenylate synthetase 1, 40/46kDa

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for OAS1

Target: OAS1 (2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1))

Alternative Name: OAS1

Background:

Synonyms: 2'-5'-oligoadenylate synthase 1 ((2-5')oligo(A) synthase 1, 2-5A synthase 1)|E18/E16|p46/p42 OAS|OAS1|OIAS

Background: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates(2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L(RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus(VSV), herpes simplex virus type 2(HSV-2), and encephalomyocarditis virus(EMCV) and stimulates the alternative antiviral pathway independent of RNase L.

Molecular Weight: 48 kDa

Gene ID: 4938

UniProt: P00973

Pathways: Hepatitis C