Aryl Hydrocarbon Receptor antibody (AA 12-215)

Catalog No. ABIN7111734

The Rabbit Polyclonal anti-Aryl Hydrocarbon Receptor antibody (ABIN7111734) specifically detects Aryl Hydrocarbon Receptor in WB, IHC, ELISA and IP. The antibody is reactive with Human and Mouse samples.

Quick Overview for Aryl Hydrocarbon Receptor antibody (AA 12-215) (ABIN7111734)

Target: Aryl Hydrocarbon Receptor (AHR)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Aryl Hydrocarbon Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)

Product Details anti-Aryl Hydrocarbon Receptor Antibody

Binding Specificity: AA 12-215

Purpose: AHR antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 12-215aa

Immunogen: aryl hydrocarbon receptor

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:2000, IP: 1:200-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for Aryl Hydrocarbon Receptor

Target: Aryl Hydrocarbon Receptor (AHR)

Alternative Name: AHR

Background:

Synonyms: Aryl hydrocarbon receptor (Ah receptor, AhR)|Class E basic helix-loop-helix protein 76 (bHLHe76)|AHR|BHLHE76

Background: Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes(such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.

Molecular Weight: 105 kDa

Gene ID: 196

UniProt: P35869

Pathways: Regulation of Cell Size