BBS1 antibody

Catalog No. ABIN7111930

This Rabbit Polyclonal antibody specifically detects BBS1 in ELISA, WB, IF and IP. It exhibits reactivity toward Human and Mouse.

Quick Overview for BBS1 antibody (ABIN7111930)

Target: BBS1 (Bardet-Biedl Syndrome 1 (BBS1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BBS1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Product Details anti-BBS1 Antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: Bardet-Biedl syndrome 1

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:1000, IP: 1:500-1:1000, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for BBS1

Target: BBS1 (Bardet-Biedl Syndrome 1 (BBS1))

Alternative Name: BBS1

Background: Synonyms:Bardet Biedl syndrome 1, BBS1, BBS2 like protein 2, BBS2L2 Background:The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor(GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog(SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.

Molecular Weight: 65 kDa

Gene ID: 582

UniProt: Q8NFJ9

Pathways: Hedgehog Signaling