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BBS1 antibody (AA 217-417) (Biotin)

BBS1 Reactivity: Human ELISA Host: Rabbit Polyclonal Biotin
Catalog No. ABIN7145232
  • Target See all BBS1 Antibodies
    BBS1 (Bardet-Biedl Syndrome 1 (BBS1))
    Binding Specificity
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 217-417
    Reactivity
    • 21
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 19
    • 1
    • 1
    Rabbit
    Clonality
    • 21
    Polyclonal
    Conjugate
    • 9
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This BBS1 antibody is conjugated to Biotin
    Application
    • 11
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Bardet-Biedl syndrome 1 protein (217-417AA)
    Isotype
    IgG
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  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    BBS1 (Bardet-Biedl Syndrome 1 (BBS1))
    Alternative Name
    BBS1 (BBS1 Products)
    Synonyms
    im:7144669 antibody, bbs2l2 antibody, BBS1 antibody, DKFZp468B1612 antibody, BBS2L2 antibody, AI451249 antibody, D19Ertd609e antibody, Bardet-Biedl syndrome 1 antibody, bardet-biedl syndrome 1 antibody, Bardet-Biedl syndrome 1 (human) antibody, BBS1 antibody, bbs1 antibody, Bbs1 antibody
    Background

    Background: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.

    Aliases: AI451249 antibody, Bardet-Biedl syndrome 1 antibody, Bardet-Biedl syndrome 1 homolog antibody, Bardet-Biedl syndrome 1 protein antibody, BBS1 antibody, BBS1_HUMAN antibody, BBS2-like protein 2 antibody, BBS2L2 antibody, D19Ertd609e antibody

    UniProt
    Q8NFJ9
    Pathways
    Hedgehog Signaling
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