CNOT3 antibody

Catalog No. ABIN7112435

The Rabbit Polyclonal anti-CNOT3 antibody has been validated for WB, ELISA, IF and IP. It is suitable to detect CNOT3 in samples from Human, Mouse and Rat.

Quick Overview for CNOT3 antibody (ABIN7112435)

Target: CNOT3 (CCR4-NOT Transcription Complex, Subunit 3 (CNOT3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CNOT3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Product Details anti-CNOT3 Antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: CCR4-NOT transcription complex, subunit 3

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:1000, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for CNOT3

Target: CNOT3 (CCR4-NOT Transcription Complex, Subunit 3 (CNOT3))

Alternative Name: CNOT3

Background: Synonyms:KIAA0691, LENG2, NOT3 Background:Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation, may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation, the repressive function may involve histone deacetylases. Involved in the maintenance of emryonic stem(ES) cell identity.

Molecular Weight: 120 kDa

Gene ID: 4849

UniProt: O75175

Pathways: Stem Cell Maintenance