CDC14B antibody

Catalog No. ABIN7112534

The Rabbit Polyclonal anti-CDC14B antibody has been validated for WB and ELISA. It is suitable to detect CDC14B in samples from Human.

Quick Overview for CDC14B antibody (ABIN7112534)

Target: CDC14B (CDC14 Cell Division Cycle 14B (CDC14B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDC14B antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CDC14B Antibody

Purpose: CDC14B antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: CDC14 cell division cycle 14 homolog B

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for CDC14B

Target: CDC14B (CDC14 Cell Division Cycle 14B (CDC14B))

Alternative Name: CDC14B

Background:

Synonyms: Dual specificity protein phosphatase CDC14B|CDC14 cell division cycle 14 homolog B|CDC14B

Background: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome(APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.

Molecular Weight: 56 kDa

Gene ID: 8555

UniProt: O60729