CISD2 antibody

Catalog No. ABIN7112541

This anti-CISD2 antibody is a Rabbit Polyclonal antibody detecting CISD2 in WB, ELISA, IHC, IF and IP. Suitable for Human, Mouse and Rat.

Quick Overview for CISD2 antibody (ABIN7112541)

Target: CISD2 (CDGSH Iron Sulfur Domain 2 (CISD2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CISD2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Product Details anti-CISD2 Antibody

Purpose: CISD2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: CDGSH iron sulfur domain 2

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for CISD2

Target: CISD2 (CDGSH Iron Sulfur Domain 2 (CISD2))

Alternative Name: CISD2

Background:

Synonyms: CDGSH iron-sulfur domain-containing protein 2|Endoplasmic reticulum intermembrane small protein|MitoNEET-related 1 protein (Miner1)|Nutrient-deprivation autophagy factor-1 (NAF-1)|CISD2|CDGSH2|ERIS|ZCD2

Background: Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.

Molecular Weight: 13-15 kDa

Gene ID: 493856

UniProt: Q8N5K1

Pathways: Activation of Innate immune Response