CHI3L1 antibody (AA 22-383)

Catalog No. ABIN7112692

This Rabbit Polyclonal antibody specifically detects CHI3L1 in IHC and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for CHI3L1 antibody (AA 22-383) (ABIN7112692)

Target: CHI3L1 (Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHI3L1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-CHI3L1 Antibody

Binding Specificity: AA 22-383

Purpose: CHI3L1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 22-383aa

Immunogen: chitinase 3-like 1(cartilage glycoprotein-39)

Isotype: IgG

Application Details

Application Notes: IHC: 1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for CHI3L1

Target: CHI3L1 (Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1))

Alternative Name: CHI3L1

Background:

Synonyms: Chitinase-3-like protein 1|39 kDa synovial protein|Cartilage glycoprotein 39 (CGP-39, GP-39, hCGP-39)|YKL-40|CHI3L1

Background: Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2(Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.

Molecular Weight: 43 kDa

Gene ID: 1116

UniProt: P36222