DHX36 antibody

Catalog No. ABIN7113365

The Rabbit Polyclonal anti-DHX36 antibody has been validated for WB, ELISA, IHC and IP. It is suitable to detect DHX36 in samples from Human, Mouse and Rat.

Quick Overview for DHX36 antibody (ABIN7113365)

Target: DHX36 (DEAH (Asp-Glu-Ala-His) Box Polypeptide 36 (DHX36))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DHX36 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Product Details anti-DHX36 Antibody

Purpose: DHX36 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: DEAH(Asp-Glu-Ala-His) box polypeptide 36

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for DHX36

Target: DHX36 (DEAH (Asp-Glu-Ala-His) Box Polypeptide 36 (DHX36))

Alternative Name: DHX36

Background:

Synonyms: ATP-dependent DNA/RNA helicase DHX36|DEAD/H box polypeptide 36|DEAH-box protein 36|G4-resolvase-1 (G4R1)|MLE-like protein 1|RNA helicase associated with AU-rich element protein|DHX36|DDX36|KIAA1488|MLEL1|RHAU

Background: Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures. Unwinds intramolecular quadruplexes derived from the ZIC1 and the MYC promoters. Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component(TERC) 5'-end(nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5'-end to promote P1 helix formation, the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation. May be involved in regulation of telomere length. Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. May play a role in ossification.

Molecular Weight: 120 kDa

Gene ID: 170506

UniProt: Q9H2U1

Pathways: Toll-Like Receptors Cascades