EPH Receptor B4 antibody

Catalog No. ABIN7113852

This anti-EPH Receptor B4 antibody is a Rabbit Polyclonal antibody detecting EPH Receptor B4 in WB, ELISA, IHC and FACS. Suitable for Human, Mouse and Rat.

Quick Overview for EPH Receptor B4 antibody (ABIN7113852)

Target: EPH Receptor B4 (EPHB4)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPH Receptor B4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Product Details anti-EPH Receptor B4 Antibody

Purpose: EPHB4 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: Extracellular,300-539AA

Immunogen: EPH receptor B4

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:5000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for EPH Receptor B4

Target: EPH Receptor B4 (EPHB4)

Alternative Name: EPHB4

Background:

Synonyms: Ephrin type-B receptor 4|Hepatoma transmembrane kinase|Tyrosine-protein kinase TYRO11|EPHB4|HTK|MYK1|TYRO11

Background: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.

Molecular Weight: 110 kDa

Gene ID: 2050

UniProt: P54760

Pathways: RTK Signaling