Eukaryotic Translation Initiation Factor 3, Subunit M (EIF3M) (AA 1-374) antibody

Catalog No. ABIN7113959

The Mouse Monoclonal anti- antibody has been validated for WB, ELISA and IF. It is suitable to detect in samples from Human.

Quick Overview for Eukaryotic Translation Initiation Factor 3, Subunit M (EIF3M) (AA 1-374) antibody (ABIN7113959)

Target: Eukaryotic Translation Initiation Factor 3, Subunit M (EIF3M)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Clone: 1A4

Product Details

Binding Specificity: AA 1-374

Purpose: EIF3M antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-374aa

Immunogen: eukaryotic translation initiation factor 3, subunit M

Isotype: IgG1

Application Details

Application Notes: WB: 1:500-1:2000, IF: 1:10-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details

Target: Eukaryotic Translation Initiation Factor 3, Subunit M (EIF3M)

Alternative Name: EIF3M

Background:

Synonyms: Eukaryotic translation initiation factor 3 subunit M (eIF3m)|Fetal lung protein B5 (hFL-B5)|PCI domain-containing protein 1|EIF3M|HFLB5|PCID1

Background: Component of the eukaryotic translation initiation factor 3(eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex(43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. May favor virus entry in case of infection with herpes simplex virus 1(HSV1) or herpes simplex virus 2(HSV2).

Molecular Weight: 43 kDa

Gene ID: 10480

UniProt: Q7L2H7

Pathways: Ribonucleoprotein Complex Subunit Organization