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EXOSC1 antibody

EXOSC1 Reactivity: Human, Mouse, Rat WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7114007
  • Target See all EXOSC1 Antibodies
    EXOSC1 (Exosome Component 1 (EXOSC1))
    Reactivity
    • 32
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 26
    • 6
    Rabbit
    Clonality
    • 28
    • 4
    Polyclonal
    Conjugate
    • 15
    • 5
    • 4
    • 4
    • 2
    • 2
    This EXOSC1 antibody is un-conjugated
    Application
    • 22
    • 22
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Purification
    Immunogen affinity purified
    Purity
    ≥95 % as determined by SDS-PAGE
    Immunogen
    exosome component 1
    Isotype
    IgG
    Top Product
    Discover our top product EXOSC1 Primary Antibody
  • Application Notes
    WB: 1:500-1:2000, IHC: 1:20-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Expiry Date
    12 months
  • Target
    EXOSC1 (Exosome Component 1 (EXOSC1))
    Alternative Name
    EXOSC1 (EXOSC1 Products)
    Synonyms
    MGC86284 antibody, CGI-108 antibody, CSL4 antibody, Csl4p antibody, SKI4 antibody, Ski4p antibody, hCsl4p antibody, p13 antibody, 2610035C18Rik antibody, 2610104C07Rik antibody, 2610312F07Rik antibody, AI447561 antibody, exosome component 1 antibody, exosome component 1 L homeolog antibody, EXOSC1 antibody, exosc1.L antibody, exosc1 antibody, PTRG_05845 antibody, Exosc1 antibody
    Background
    Synonyms:CSL4 Background:Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination(CSR) and/or Ig variable region somatic hypermutation(SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits(Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8.
    Molecular Weight
    21 kDa
    Gene ID
    51013
    UniProt
    Q9Y3B2
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