FANCL antibody

Catalog No. ABIN7114121

The Rabbit Polyclonal anti-FANCL antibody is suitable to detect FANCL in samples from Human and Mouse. It has been validated for WB, ELISA and IHC.

Quick Overview for FANCL antibody (ABIN7114121)

Target: FANCL (Fanconi Anemia, Complementation Group L (FANCL))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FANCL antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-FANCL Antibody

Purpose: FANCL antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: Fanconi anemia, complementation group L

Isotype: IgG

Application Details

Application Notes: WB: 1:200 - 1:2000, IHC: 1:20 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for FANCL

Target: FANCL (Fanconi Anemia, Complementation Group L (FANCL))

Alternative Name: FANCL

Background:

Synonyms: E3 ubiquitin-protein ligase FANCL|Fanconi anemia group L protein|Fanconi anemia-associated polypeptide of 43 kDa (FAAP43)|RING-type E3 ubiquitin transferase FANCL|FANCL|PHF9

Background: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity, they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group L. Alternative splicing results in two transcript variants encoding different isoforms.

Molecular Weight: 38 kDa

Gene ID: 55120

UniProt: Q9NW38

Pathways: DNA Damage Repair