Fibrinogen beta Chain antibody (AA 150-491)

Catalog No. ABIN7114194

This anti-Fibrinogen beta Chain antibody is a Mouse Monoclonal antibody detecting Fibrinogen beta Chain in WB and ELISA. Suitable for Human.

Quick Overview for Fibrinogen beta Chain antibody (AA 150-491) (ABIN7114194)

Target: Fibrinogen beta Chain (FGB)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Fibrinogen beta Chain antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 6F4

Product Details anti-Fibrinogen beta Chain Antibody

Binding Specificity: AA 150-491

Purpose: FGB antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 150-491aa

Immunogen: fibrinogen beta chain

Isotype: IgG2a

Application Details

Application Notes: WB: 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for Fibrinogen beta Chain

Target: Fibrinogen beta Chain (FGB)

Alternative Name: FGB

Background:

Synonyms: Fibrinogen beta chain|Fibrinopeptide B|Fibrinogen beta chain|FGB

Background: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha(FGA) and fibrinogen gamma(FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.

Molecular Weight: 50 kDa

Gene ID: 2244

UniProt: P02675