FRS2 antibody

Catalog No. ABIN7114220

The Rabbit Polyclonal anti-FRS2 antibody has been validated for WB, ELISA, IHC and IF. It is suitable to detect FRS2 in samples from Human, Mouse and Rat.

Quick Overview for FRS2 antibody (ABIN7114220)

Target: FRS2 (Fibroblast Growth Factor Receptor Substrate 2 (FRS2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FRS2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-FRS2 Antibody

Purpose: FRS2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: fibroblast growth factor receptor substrate 2

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:5000, IHC: 1:20-1:200, IF: 1:10-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for FRS2

Target: FRS2 (Fibroblast Growth Factor Receptor Substrate 2 (FRS2))

Alternative Name: FRS2

Background:

Synonyms: Fibroblast growth factor receptor substrate 2 (FGFR substrate 2)|FGFR-signaling adaptor SNT|Suc1-associated neurotrophic factor target 1 (SNT-1)|FRS2

Background: Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

Molecular Weight: 60 kDa

Gene ID: 10818

UniProt: Q8WU20

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Signaling Events mediated by VEGFR1 and VEGFR2