Fibronectin 1 antibody (AA 2268-2477)

Catalog No. ABIN7114225

This Mouse Monoclonal antibody specifically detects Fibronectin 1 in WB, ELISA, IHC and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for Fibronectin 1 antibody (AA 2268-2477) (ABIN7114225)

Target: Fibronectin 1 (FN1)

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This Fibronectin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Clone: 3G6

Product Details anti-Fibronectin 1 Antibody

Binding Specificity: AA 2268-2477

Purpose: FN1 antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 2268-2477aa

Immunogen: fibronectin 1

Isotype: IgG2a

Application Details

Application Notes: WB: 1:2000-1:10000, IHC: 1:300-1:1000, IF: 1:50-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for Fibronectin 1

Target: Fibronectin 1 (FN1)

Alternative Name: FN1

Background:

Synonyms: Fibronectin (FN)|Cold-insoluble globulin (CIG)|Anastellin|Ugl-Y1|Ugl-Y2|Ugl-Y3|FN1|FN

Background: Fibronectin 1(FN1) is a high molecular weight glycoprotein which exists in both a soluble form in plasma(plasma FN1) and other body fluids and an insoluble form in the extracellular matrix(cellular FN1). Plasma FN1(dimeric form) is secreted by hepatocytes. Cellular FN(dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. FN1 binds to cell surfaces through integrins and to various compounds including collagen, fibrin and heparin. It is involved in cell adhesion and migration processes including embryogenesis, wound healing, hemostasis, host defense, and metastasis.(PMID: 7276612, 12244123, 12847088)

Molecular Weight: 260 kDa

Gene ID: 2335

UniProt: P02751

Pathways: Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy