GPR161 antibody

Catalog No. ABIN7114407

This anti-GPR161 antibody is a Rabbit Polyclonal antibody detecting GPR161 in WB, ELISA and IHC. Suitable for Human, Mouse and Rat.

Quick Overview for GPR161 antibody (ABIN7114407)

Target: GPR161 (G Protein-Coupled Receptor 161 (GPR161))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPR161 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-GPR161 Antibody

Purpose: GPR161 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: G protein-coupled receptor 161

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for GPR161

Target: GPR161 (G Protein-Coupled Receptor 161 (GPR161))

Alternative Name: GPR161

Background:

Synonyms: G-protein coupled receptor 161|G-protein coupled receptor RE2|GPR161

Background: Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown(By similarity).

Molecular Weight: 70 kDa

Gene ID: 23432

UniProt: Q8N6U8

Pathways: cAMP Metabolic Process