GSDMD antibody (AA 276-484)

Catalog No. ABIN7114492

This Rabbit Polyclonal antibody specifically detects GSDMD in WB, ELISA, IF and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for GSDMD antibody (AA 276-484) (ABIN7114492)

Target: GSDMD (Gasdermin D (GSDMD))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GSDMD antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Product Details anti-GSDMD Antibody

Binding Specificity: AA 276-484

Purpose: GSDMD antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 276-484aa

Immunogen: gasdermin D

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:2000, IHC: 1:20-1:200, IF: 1:10-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for GSDMD

Target: GSDMD (Gasdermin D (GSDMD))

Alternative Name: GSDMD

Background:

Synonyms: Gasdermin-D|Gasdermin domain-containing protein 1|Gasdermin-D, C-terminal (GSDMD-CT, hGSDMD-CTD)|Gasdermin-D, p13|Gasdermin-D, 13 kDa (13 kDa GSDMD)|Gasdermin-D, p40|GSDMD|DFNA5L|GSDMDC1

Background: GSDMD is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. GSDMD has been suggested to act as a tumor suppressor. Recently, GSDMD is identified as a new component of inflammasomes, and it is an executor of pyroptosis and required for interleukin-1β secretion. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.

Molecular Weight: 50-53 kDa

Gene ID: 79792

UniProt: P57764

Pathways: Inflammasome