GEMIN5 antibody

Catalog No. ABIN7114527

This anti-GEMIN5 antibody is a Rabbit Polyclonal antibody detecting GEMIN5 in WB, IP, ELISA, IHC and IF. Suitable for Human.

Quick Overview for GEMIN5 antibody (ABIN7114527)

Target: GEMIN5 (Gem (Nuclear Organelle) Associated Protein 5 (GEMIN5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GEMIN5 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-GEMIN5 Antibody

Purpose: GEMIN5 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: gem(nuclear organelle) associated protein 5

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000, IP: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:10-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for GEMIN5

Target: GEMIN5 (Gem (Nuclear Organelle) Associated Protein 5 (GEMIN5))

Alternative Name: GEMIN5

Background:

Synonyms: Gem-associated protein 5 (Gemin5)|GEMIN5

Background: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins(snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. GEMIN5 acts as the snRNA-binding protein of the SMN complex.

Molecular Weight: 168 kDa

Gene ID: 25929

UniProt: Q8TEQ6

Pathways: Ribonucleoprotein Complex Subunit Organization