Glutathione Peroxidase 2 antibody

Catalog No. ABIN7114637

The Rabbit Polyclonal anti-Glutathione Peroxidase 2 antibody has been validated for ELISA, WB and IHC. It is suitable to detect Glutathione Peroxidase 2 in samples from Human, Mouse and Rat.

Quick Overview for Glutathione Peroxidase 2 antibody (ABIN7114637)

Target: Glutathione Peroxidase 2 (GPX2)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Glutathione Peroxidase 2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Glutathione Peroxidase 2 Antibody

Purpose: GPX2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: Glutathione peroxidase 2

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for Glutathione Peroxidase 2

Target: Glutathione Peroxidase 2 (GPX2)

Alternative Name: GPX2

Background:

Synonyms: Glutathione peroxidase 2 (GPx-2, GSHPx-2)|Gastrointestinal glutathione peroxidase|Glutathione peroxidase-gastrointestinal (GPx-GI, GSHPx-GI)|Glutathione peroxidase-related protein 2 (GPRP-2)|Phospholipid hydroperoxide glutathione peroxidase GPX2|GPX2

Background: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.

Molecular Weight: 21 kDa

UniProt: P18283

Pathways: Thyroid Hormone Synthesis