GADD45GIP1 antibody

Catalog No. ABIN7114772

The Rabbit Polyclonal anti-GADD45GIP1 antibody is suitable to detect GADD45GIP1 in samples from Human, Mouse and Rat. It has been validated for ELISA, WB and IP.

Quick Overview for GADD45GIP1 antibody (ABIN7114772)

Target: GADD45GIP1 (Growth Arrest and DNA-Damage-Inducible, gamma Interacting Protein 1 (GADD45GIP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GADD45GIP1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-GADD45GIP1 Antibody

Purpose: GADD45GIP1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: growth arrest and DNA-damage-inducible, gamma interacting protein 1

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for GADD45GIP1

Target: GADD45GIP1 (Growth Arrest and DNA-Damage-Inducible, gamma Interacting Protein 1 (GADD45GIP1))

Alternative Name: GADD45GIP1

Background:

Synonyms: Large ribosomal subunit protein mL64|39S ribosomal protein L59, mitochondrial (MRP-L59)|CKII beta-associating protein|CR6-interacting factor 1 (CRIF1)|Growth arrest and DNA damage-inducible proteins-interacting protein 1|Papillomavirus L2-interacting nuclear protein 1 (PLINP, PLINP-1)|p53-responsive gene 6 protein|GADD45GIP1|MRPL59|PLINP1|PRG6

Background: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.

Molecular Weight: 25-28 kDa

Gene ID: 90480

UniProt: Q8TAE8