K-RAS antibody (AA 1-189)

Catalog No. ABIN7114805

The Rabbit Polyclonal anti-K-RAS antibody has been validated for WB, ELISA, IHC and IP. It is suitable to detect K-RAS in samples from Human, Rat and Mouse.

Quick Overview for K-RAS antibody (AA 1-189) (ABIN7114805)

Target: K-RAS (KRAS) (GTPase Kras (KRAS))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This K-RAS antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Product Details anti-K-RAS Antibody

Binding Specificity: AA 1-189

Purpose: KRAS antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-189aa

Immunogen: v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

Isotype: IgG

Application Details

Application Notes: WB: 1:500 - 1:1000, IHC: 1:50 - 1:200, IP: 1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for K-RAS

Target: K-RAS (KRAS) (GTPase Kras (KRAS))

Alternative Name: KRAS

Background:

Synonyms: GTPase KRas|K-Ras 2|Ki-Ras|c-K-ras|c-Ki-ras|GTPase KRas, N-terminally processed|KRAS|KRAS2|RASK2

Background: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation(PubMed:23698361, PubMed:22711838). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes(TSGs) in colorectal cancer(CRC) cells in a ZNF304-dependent manner(PubMed:24623306).

Molecular Weight: 21 kDa

Gene ID: 3845

UniProt: P01116