HLTF antibody

Catalog No. ABIN7114924

This Rabbit Polyclonal antibody specifically detects HLTF in WB and ELISA. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for HLTF antibody (ABIN7114924)

Target: HLTF (Helicase-Like Transcription Factor (HLTF))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HLTF antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-HLTF Antibody

Purpose: HLTF antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: helicase-like transcription factor

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for HLTF

Target: HLTF (Helicase-Like Transcription Factor (HLTF))

Alternative Name: HLTF

Background:

Synonyms: Helicase-like transcription factor|DNA-binding protein/plasminogen activator inhibitor 1 regulator|HIP116|RING finger protein 80|RING-type E3 ubiquitin transferase HLTF|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3|Sucrose nonfermenting protein 2-like 3|HLTF|HIP116A|RNF80|SMARCA3|SNF2L3|ZBU1

Background: Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity, This activity may be required for transcriptional activation or repression of specific target promoters(By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair(PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.

Molecular Weight: 114 kDa

Gene ID: 6596

UniProt: Q14527