HSD17B10 antibody (AA 1-261)

Catalog No. ABIN7115148

This anti-HSD17B10 antibody is a Mouse Monoclonal antibody detecting HSD17B10 in WB and ELISA. Suitable for Human and Mouse.

Quick Overview for HSD17B10 antibody (AA 1-261) (ABIN7115148)

Target: HSD17B10 (Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This HSD17B10 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 6C4

Product Details anti-HSD17B10 Antibody

Binding Specificity: AA 1-261

Purpose: HSD17B10 antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-261aa

Immunogen: hydroxysteroid(17-beta) dehydrogenase 10

Isotype: IgG1

Application Details

Application Notes: WB: 1:1000-1:4000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for HSD17B10

Target: HSD17B10 (Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10))

Alternative Name: HSD17B10

Background:

Synonyms: 3-hydroxyacyl-CoA dehydrogenase type-2|17-beta-estradiol 17-dehydrogenase|2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD)|3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))|3-hydroxy-2-methylbutyryl-CoA dehydrogenase|3-hydroxyacyl-CoA dehydrogenase type II|3alpha(or 20beta)-hydroxysteroid dehydrogenase|7-alpha-hydroxysteroid dehydrogenase|Endoplasmic reticulum-associated amyloid beta-peptide-binding protein|Mitochondrial ribonuclease P protein 2 (Mitochondrial RNase P protein 2)|Short chain dehydrogenase/reductase family 5C member 1|Short-chain type dehydrogenase/reductase XH98G2|Type II HADH|HSD17B10|ERAB|HADH2|MRPP2|SCHAD|SDR5C1|XH98G2

Background: Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease(AD).

Molecular Weight: 27 kDa

Gene ID: 3028

UniProt: Q99714