IL-18 antibody

Catalog No. ABIN7115433

This anti-IL-18 antibody is a Rabbit Polyclonal antibody detecting IL-18 in WB, IHC, IP, ELISA and IF. Suitable for Human and Rat.

Quick Overview for IL-18 antibody (ABIN7115433)

Target: IL-18 (IL18) (Interleukin 18 (IL18))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-18 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), ELISA, Immunofluorescence (IF)

Product Details anti-IL-18 Antibody

Purpose: Pre-IL18 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: interleukin 18(interferon-gamma-inducing factor)

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:500-1:5000 , IHC: 1:50-1:500, IF: 1:10-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for IL-18

Target: IL-18 (IL18) (Interleukin 18 (IL18))

Alternative Name: Pre-IL18

Background:

Synonyms: Interleukin-18 (IL-18)|Iboctadekin|Interferon gamma-inducing factor (IFN-gamma-inducing factor)|Interleukin-1 gamma (IL-1 gamma)|IL18|IGIF|IL1F4

Background: IL18, is a proinflammatory cytokine involved in the development of Th1 cells and in immune response. It can stimulate the NK cells and certain T cells to release interferon gamma which plays an important role in activating the macrophages or other cells. IL18 has been demonstrated to have the potential to enhance Fas ligand-mediated cytotoxicity, which is increased in PE and regulates placental apoptosis. IL18 is synthesized as a 24 kDa precursor and then cleaved into a biologically activate 18 kDa form. This antibody is raised against the full length IL18 precursor, and it recognizes both the pre-IL18 and mature IL18 theoretically.

Molecular Weight: 24 kDa

UniProt: Q14116

Pathways: Cellular Response to Molecule of Bacterial Origin, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome