IL-6 Receptor antibody

Catalog No. ABIN7115473

This Rabbit Polyclonal antibody specifically detects IL-6 Receptor in WB, IHC, IP and ELISA. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for IL-6 Receptor antibody (ABIN7115473)

Target: IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-6 Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), ELISA

Product Details anti-IL-6 Receptor Antibody

Purpose: IL6R antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: P08887-1,229-468

Immunogen: interleukin 6 receptor

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:1000, IHC: 1:50-1:200, IP: 1:500-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for IL-6 Receptor

Target: IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

Alternative Name: IL6R

Background:

Synonyms: Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R-alpha, IL-6RA)|IL-6R 1|Membrane glycoprotein 80 (gp80)|Soluble interleukin-6 receptor subunit alpha (sIL6R)|IL6R

Background: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.

Molecular Weight: 80 kDa

Gene ID: 3570

UniProt: P08887

Pathways: JAK-STAT Signaling, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints