IQCB1 antibody

Catalog No. ABIN7115509

This Rabbit Polyclonal antibody specifically detects IQCB1 in ELISA and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for IQCB1 antibody (ABIN7115509)

Target: IQCB1 (IQ Motif Containing B1 (IQCB1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IQCB1 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF)

Product Details anti-IQCB1 Antibody

Purpose: IQCB1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: IQ motif containing B1

Isotype: IgG

Application Details

Application Notes: IF: 1:10-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for IQCB1

Target: IQCB1 (IQ Motif Containing B1 (IQCB1))

Alternative Name: IQCB1

Background:

Synonyms: IQ calmodulin-binding motif-containing protein 1|Nephrocystin-5|p53 and DNA damage-regulated IQ motif protein (PIQ)|IQCB1|KIAA0036|NPHP5

Background: IQCB1, also known as NPHP5, is a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. It has a central coiled-coil region and two calmodulin-binding IQ domains. Localized to the primary cilia of renal epithelial cells and connecting cilia of photoreceptor cells, IQCB1 is thought to play a role in ciliary function. Mutations in this gene result in Senior-Loken syndrome type 5, a juvenile disorder characterized by defects in the waste filtering system of the kidney, as well as retinal degradation.

UniProt: Q15051