Cytokeratin 18 antibody (AA 127-430)

Catalog No. ABIN7115628

This anti-Cytokeratin 18 antibody is a Mouse Monoclonal antibody detecting Cytokeratin 18 in WB, IHC, IF, FACS and ELISA. Suitable for Human, Mouse and Rat.

Quick Overview for Cytokeratin 18 antibody (AA 127-430) (ABIN7115628)

Target: Cytokeratin 18 (KRT18) (Keratin 18 (KRT18))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cytokeratin 18 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), ELISA

Clone: 6E3

Product Details anti-Cytokeratin 18 Antibody

Binding Specificity: AA 127-430

Purpose: KRT18 antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 127-430aa

Immunogen: keratin 18

Isotype: IgG2a

Application Details

Application Notes: WB: 1:5000-1:30000, IHC: 1:500-1:1000, IF: 1:100-1:300

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for Cytokeratin 18

Target: Cytokeratin 18 (KRT18) (Keratin 18 (KRT18))

Alternative Name: KRT18

Background:

Synonyms: Keratin, type I cytoskeletal 18|Cell proliferation-inducing gene 46 protein|Cytokeratin-18 (CK-18)|Keratin-18 (K18)|KRT18|CYK18

Background: Keratins are a large family of proteins that form the intermediate filament cytoskeleton of epithelial cells, which are classified into two major sequence types. Type I keratins are a group of acidic intermediate filament proteins, including K9-K23, and the hair keratins Ha1-Ha8. Type II keratins are the basic or neutral courterparts to the acidic type I keratins, including K1-K8, and the hair keratins, Hb1-Hb6. KRT18, also named as CYK18, PIG46 and K18, is the most commonly found members of the intermediate filament gene family. KRT18 is a type I keratin which is found primarily in non squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas but not in squamous cell carcinomas.

Molecular Weight: 48 kDa

Gene ID: 3875

UniProt: P05783

Pathways: Apoptosis, Caspase Cascade in Apoptosis