KDM5C antibody

Catalog No. ABIN7115965

This Rabbit Polyclonal antibody specifically detects KDM5C in ELISA and WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for KDM5C antibody (ABIN7115965)

Target: KDM5C (Lysine (K)-Specific Demethylase 5C (KDM5C))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KDM5C antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-KDM5C Antibody

Purpose: KDM5C antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: lysine(K)-specific demethylase 5C

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for KDM5C

Target: KDM5C (Lysine (K)-Specific Demethylase 5C (KDM5C))

Alternative Name: KDM5C

Background:

Synonyms: Lysine-specific demethylase 5C|Histone demethylase JARID1C|Jumonji/ARID domain-containing protein 1C|Protein SmcX|Protein Xe169|[histone H3]-trimethyl-L-lysine(4) demethylase 5C|KDM5C|DXS1272E|JARID1C|SMCX|XE169

Background: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2(By similarity).

Molecular Weight: 171-180 kDa

Gene ID: 8242

UniProt: P41229

Pathways: Warburg Effect