MARK4 antibody

Catalog No. ABIN7116062

The Rabbit Polyclonal anti-MARK4 antibody has been validated for ELISA and IHC. It is suitable to detect MARK4 in samples from Human, Mouse and Rat.

Quick Overview for MARK4 antibody (ABIN7116062)

Target: MARK4 (MAP/microtubule Affinity-Regulating Kinase 4 (MARK4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MARK4 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-MARK4 Antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: MAP/microtubule affinity-regulating kinase 4

Isotype: IgG

Application Details

Application Notes: IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for MARK4

Target: MARK4 (MAP/microtubule Affinity-Regulating Kinase 4 (MARK4))

Alternative Name: MARK4

Background: Synonyms:KIAA1860, MARKL1 Background:Serine/threonine-protein kinase(PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT(PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4(PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles(PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly(PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro(PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint(PubMed:25123532). Reduces neuronal cell survival(PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate(By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway(By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation(PubMed:23184942).

Gene ID: 57787

UniProt: Q96L34